The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation
نویسندگان
چکیده
منابع مشابه
The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation
STUDY QUESTION What is the prevalence of defects in the Ca(2+)-signalling pathways mediating hyperactivation (calcium influx and store mobilization) among donors and sub-fertile patients and are they functionally significant, i.e. related to fertilization success at IVF? SUMMARY ANSWER This study identifies, for the first time, the prevalence of Ca(2+) store defects in sperm from research don...
متن کاملMathematical Modeling of Calcium Signaling in Sperm Mathematical modeling of calcium signaling during sperm hyperactivation
Mammalian sperm must hyperactivate in order to fertilize oocytes. Hyperactivation is characterized by highly asymmetrical flagellar bending. It serves to move sperm out of the oviductal reservoir and to penetrate viscoelastic fluids, such as the cumulus matrix. It is absolutely required for sperm penetration of the oocyte zona pellucida. In order for sperm to hyperactivate, cytoplasmic Ca level...
متن کاملMathematical modeling of calcium signaling during sperm hyperactivation.
Mammalian sperm must hyperactivate in order to fertilize oocytes. Hyperactivation is characterized by highly asymmetrical flagellar bending. It serves to move sperm out of the oviductal reservoir and to penetrate viscoelastic fluids, such as the cumulus matrix. It is absolutely required for sperm penetration of the oocyte zona pellucida. In order for sperm to hyperactivate, cytoplasmic Ca(2+) l...
متن کاملThe mechanics of hyperactivation in adhered human sperm
Hyperactivation is an important phenomenon exhibited by mammalian sperm during the process of acquiring fertilization capacity. The majority of studies have focused on incubation-induced hyperactivation in non-human species, which typically differ in size, shape, and are more homogeneous than human sperm. We develop an alternative approach via drug-induction, using high-speed imaging and analys...
متن کاملControl of hyperactivation in sperm.
BACKGROUND Sperm hyperactivation is critical to fertilization, because it is required for penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from the oviductal storage reservoir and may propel sperm through mucus in the oviductal lumen and the matrix of the cumulus oophorus. Hyperactivation is characterized by high amplitude, asymmetrical flagellar bending. ...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2013
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/des467